Top-down venomics of the East African green mamba, Dendroaspis angusticeps , and the black mamba, Dendroaspis polylepis , highlight the complexity of their toxin arsenals
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چکیده
منابع مشابه
Black mamba dendroaspis polylepis bite: a case report.
Although very rare in a European context, a bite from the black mamba Dendroaspis polylepis is an event that poses an immediate threat to life. Given the content of neurotoxins in the snake's venom, the mortality of envenomation reaches 100% in almost every case if ventilation is not provided in a timely manner and adequate therapy initiated. The report d...
متن کاملIsolation of a Postynaptic Blocker from the Venom of the Green Mamba, Dendroaspis angusticeps
A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...
متن کاملIsolation of a Postsynaptic Blocker from the Venom of the Green Mamba, Dendroaspis Angusticeps
A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...
متن کاملToxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).
UNLABELLED A toxicovenomic study was performed on the venom of the green mamba, Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of D. angusticeps, in addition to the nucleoside adenosine. The most abundant proteins belong to the three-finger toxin (3FTx) (69.2%) and the Kunitz-type proteinase inhibitor (16.3%) families. Several sub-subfamilies of the 3FTxs wer...
متن کاملAn Unexpected Case of Black Mamba (Dendroaspis polylepis) Bite in Switzerland
Mambas (genus Dendroaspis) are among the most feared venomous African snakes. Without medical treatment, mamba bites are frequently fatal. First-aid treatment includes lymphatic retardation with the pressure immobilization technique. Medical management comprises continuous monitoring, securing patency of the airway, ensuring adequate ventilation, symptomatic measures, and administration of spec...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2016
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2016.06.018